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  • Title: [Hydrogen currents through aconitine-modified sodium channels in nerve fiber membranes].
    Author: Mozhaeva GN, Naumov AP.
    Journal: Neirofiziologiia; 1982; 14(5):508-16. PubMed ID: 6292750.
    Abstract:
    Ionic currents in nodal membrane treated with aconitine were measured under voltage clamp conditions when nodes were bathed in Na-free solutions. At pH lower than 4.6 inward ionic currents were detected which had kinetics and voltage range of activation analogous to those of aconitine-modified sodium channels at low pH. These currents were blocked by benzocaine (2 mM). Experiments with various concentrations of Ca2+, tris+, TEA+, choline+ ions showed that these ions are essentially impermeable both at normal and acidic pH. It is concluded that the inward currents observed are carried by H+ (or H3O+) ions through aconitine-modified sodium channels. From reversal potential measurements relative permeability (PH/PNa) of sodium channels is estimated to be 1059 +/- 88. The results suggest that the aconitine-modified channel is a rather wide water-filled pore and the rate of H+ passing through the channel is limited by its binding to an acidic group.
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