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  • Title: Morphine catalepsy in the rat: involvement of mu 1 (high affinity) opioid binding sites.
    Author: Ling GS, Pasternak GW.
    Journal: Neurosci Lett; 1982 Oct 08; 32(2):193-6. PubMed ID: 6292799.
    Abstract:
    Since the proposal of multiple classes of opiate receptors, much effort has been devoted to understanding the subtypes mediating specific opioid actions. Using the irreversible antagonist naloxazone, we have established a role for the high affinity (mu 1) sites in analgesia. These sites also appear important in opiate catalepsy. Control rats showed dramatic catalepsy following a high dose of morphine sulfate (100 mg/kg, s.c.). Rats whose high affinity (mu 1) sites had been blocked with naloxazone 24 h earlier, on the other hand, showed no evidence of catalepsy (P less than 0.01). Accordingly, catalepsy appears to involve the same receptors as analgesia, the higher affinity (mu 1) sites.
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