These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Changes in hydrolytic lysosomal enzymes of liver associated with protein and protein-calorie malnutrition].
    Author: Muñoz-Martínez E, Marcos A, Unzaga MT, Varela G.
    Journal: Rev Esp Fisiol; 1982; 38 Suppl():327-33. PubMed ID: 6293017.
    Abstract:
    The effect of a low protein (1%) diet (protein-deficient diet) and a low protein-calorie diet (restricted diet) on the activity of the hydrolytic enzymes acid ribonuclease, acid deoxiribonuclease, acid and alkaline phosphatases and beta-glucuronidase has been studied in the liver of Wistar rts. Experimentation was carried out over 30 days and then comparisons were made against well-nourished (10% protein, controls), and one another. Body weight of deficient animals decreased in deficient animals, especially in protein-deficient rats. Liver weight also dropped significantly in malnourished rats. In terms of organ weight relative to body weight, there was a clear increase of protein-deficient rats, compared with controls. Enzyme activities expressed per total organ fell significantly in deficient rats compared with controls, but alkaline phosphatase activity increased. A large increase in hydrolytic activity expressed per mg of protein in beta-glucuronidase and alkaline phosphatase values was registered in protein-deficient and restricted rats. Also, acid ribonuclease activity increased in deficient-protein animals, but it fell in protein-calorie deficient animals compared with controls. However, acid deoxiribunuclease and acid phosphatase activities were not modified. We therefore concluded that protein-deficient and restricted diets increase catabolism in liver through a modulation of lysosomal hydrolase activities.
    [Abstract] [Full Text] [Related] [New Search]