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  • Title: The effect of ACTH on rat brain synaptic plasma membrane lipid fluidity.
    Author: Hershkowitz M, Zwiers H, Gispen WH.
    Journal: Biochim Biophys Acta; 1982 Nov 22; 692(3):495-7. PubMed ID: 6293574.
    Abstract:
    The effect of ACTH on the lipid fluidity was examined in synaptic plasma membranes from rat forebrain. ACTH1-24 increased the fluidity of the synaptic plasma membranes in a dose-dependent way, the lowest effective dose being 10(-5) M. The shorter N-terminal fragment ACTH1-10 was not effective. The significance of this finding is discussed in relation to the known effects of ACTH on synaptic membrane phosphorylation.
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