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  • Title: Interaction of descending spinal sympathetic pathways and afferent nerves.
    Author: Barman SM, Wurster RD.
    Journal: Am J Physiol; 1978 Mar; 234(3):H223-9. PubMed ID: 629359.
    Abstract:
    With the use of computer-aided techniques, the interaction of descending spinal sympathetic pathways and afferent nerve fibers (cervical dorsal roots and tibial nerve) in regulation of thoracic (T2) preganglionic nerve activity was investigated in anesthetized, vagotomized, and paralyzed cats. High-frequency activation of a sympathoinhibitory pathway (ventrolateral funiculus) depressed the evoked discharges in the T2 preganglionic nerve elicited by stimulation of a sympathoexcitatory pathway (dorsolateral funiculus) and the spinal component of the somatosympathetic reflex. Submaximal evoked responses were also inhibited through baroreceptor reflex activation (blood pressure elevations up to 225 mmHg). Facilitation of the spinal component of the somatosympathetic reflex occurred during stimulation of the excitatory pathway. Carotid occlusion (baroreceptor inactivation) facilitated the submaximal evoked discharges from stimulation of the descending excitatory pathway. These data support the contention that sympathetic nerve activity can be modified by the integration of excitatory and inhibitory impulses at the spinal level.
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