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  • Title: [Mechanism of action of cyproheptadine (peritol) on the hypothalamo-pituitary-adrenal axis].
    Author: Slavnov VN, Valueva GV, Luchitskiĭ EV.
    Journal: Biull Eksp Biol Med; 1982 Sep; 94(9):71-3. PubMed ID: 6293623.
    Abstract:
    The present paper is concerned with the mechanism of action of the blocker of serotonin receptors, cyproheptadine (peritol) on the hypothalamohypophyseal-adrenal system activity. It has been established in male rats that the inhibitory, antiserotonin action of peritol on the indicated system activity depends on the rate and rhythmicity of the drug administration, and, to a less degree, on its dosage. Peritol exerts a specific antiserotonin action via the CNS and by acting on some regulatory mechanism in peripheral tissues (adenylate cyclase system, corticosterone secretion).
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