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  • Title: Excitatory effects of ACTH on noradrenergic neurons of the locus coeruleus in the rat.
    Author: Olpe HR, Jones RS.
    Journal: Brain Res; 1982 Nov 11; 251(1):177-9. PubMed ID: 6293647.
    Abstract:
    Responses of presumed noradrenaline-containing neurons in locus coeruleus (LC) to iontophoretically applied ACTH were determined. The full sequence ACTH1-39 and the partial sequence ACTH1-24 were excitatory on the majority of neurons tested. The partial sequence ACTH27-39 was without effect on most neurons. The presence of ACTH-containing fibers in LC together with the present results may suggest a controlling influence of the peptide on the noradrenaline system.
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