These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Spread of virus and distribution of latent infection following ocular herpes simplex in the non-immune and immune mouse.
    Author: Tullo AB, Shimeld C, Blyth WA, Hill TJ, Easty DL.
    Journal: J Gen Virol; 1982 Nov; 63 (Pt 1)():95-101. PubMed ID: 6294236.
    Abstract:
    In both non-immune and immune mice infected with herpes simplex virus the incidence of latent infection of the trigeminal ganglion was related to the severity of ocular virus infection. During primary infection, virus was shown to travel via the ophthalmic part of the ganglion to reach the brainstem, from where centrifugal spread resulted in latent infection of neurones in the trigeminal ganglion which did not serve the site of inoculation. Primary infection also resulted in latent infection of the superior cervical ganglion. Shedding of virus occurred rarely in the tears of animals which had recovered from primary disease. In immune mice, spread of virus resulted in a much lower incidence of latent infection and that occurred only in ophthalmic neurones.
    [Abstract] [Full Text] [Related] [New Search]