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  • Title: The roles of individual polyoma virus early proteins in oncogenic transformation.
    Author: Rassoulzadegan M, Cowie A, Carr A, Glaichenhaus N, Kamen R, Cuzin F.
    Journal: Nature; 1982 Dec 23; 300(5894):713-8. PubMed ID: 6294529.
    Abstract:
    The expression in normal rat cells of modified polyoma virus genomes, separately encoding large T, middle T or small T antigens, has allowed the investigation of the roles of these proteins in oncogenic transformation. Middle T is sufficient to transform cells of established lines but the transformants are serum dependent. Large T lacks intrinsic oncogenic potential but can relieve the serum dependence of normal and transformed cells. Middle T alone cannot transform primary rat embryo fibroblasts.
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