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  • Title: Conditioned taste aversion following acutely administered acrylamide.
    Author: Anderson CE, Tilson HA, Mitchell CL.
    Journal: Neurobehav Toxicol Teratol; 1982; 4(5):497-9. PubMed ID: 6294541.
    Abstract:
    Fischer-344 rats were acclimated to a daily 15 min period of water availability. After water consumption had stabilized, the rats were permitted a 15 min access to 0.15% (w/v) solution of saccharin. One to two min following saccharin presentation, they were given various doses of acrylamide (10-50 mg/kg) or lithium chloride (LiCl; 3 mEq/kg) by gavage. Three days later, aversion to the saccharin solution was determined. Acrylamide, like LiCl, produced an aversion to saccharin. The effect of acrylamide appeared to be dose-related with the threshold dose being 10 mg/kg.
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