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  • Title: Associative conditioning of single sensory neurons suggests a cellular mechanism for learning.
    Author: Walters ET, Byrne JH.
    Journal: Science; 1983 Jan 28; 219(4583):405-8. PubMed ID: 6294834.
    Abstract:
    A cellular analog of associative learning has been demonstrated in individual sensory neurons of the tail withdrawal reflex of Aplysia. Sensory cells activated by intracellular current injection shortly before a sensitizing shock to the animal's tail display significantly more facilitation of their monosynaptic connections to a tail motor neuron than cells trained either with intracellular stimulation unpaired to tail shock or with tail shock alone. This associative effect is acquired rapidly and is expressed as a temporally specific amplification of heterosynaptic facilitation. The results suggest that activity-dependent neuromodulation may be a mechanism underlying associative information storage and point to aspects of subcellular processes that might be involved in the formation of neural associations.
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