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  • Title: A benzodiazepine receptor antagonist decreases sleep and reverses the hypnotic actions of flurazepam.
    Author: Mendelson WB, Cain M, Cook JM, Paul SM, Skolnick P.
    Journal: Science; 1983 Jan 28; 219(4583):414-6. PubMed ID: 6294835.
    Abstract:
    The benzodiazepine receptor antagonist 3-hydroxymethyl-beta-carboline, which blocks several of the pharmacological actions of benzodiazepines, induces a dose-dependent increase in sleep latency in the rat. Furthermore, at a low dose that by itself does not affect sleep, 3-hydroxymethyl-beta-carboline blocks sleep induction by a large dose of flurazepam. The benzodiazepine receptor may play a role in both the physiological regulation and pharmacological induction of sleep.
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