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  • Title: A study of the circadian rhythm in 3, 5 cAMP in bronchial asthma after administration of ketotifen.
    Author: Fernández M, Neffen H, Sanz ML, Oehling A.
    Journal: Allergol Immunopathol (Madr); 1981; 9(5):405-10. PubMed ID: 6295126.
    Abstract:
    A study of the circadian rhythm of cAMP is carried out in ten patients suffering from mixed bronchial asthma, with a marked bacterial component and with sensitizations due to pneumo-allergens (house dust and Dermatophagoides). Cyclic AMP levels were determined before and after treatment with Ketotifen (HC-20511). At the same time, cAMP levels were determined in a control group of 10 healthy subjects in order to realize a comparative study with the asthmatic group. Blood was drawn beginning at 5 AM. at four hour intervals for 24 hours. During this period, medication was withdrawn from these patients, although in some cases antibiotics and mucolytics were administered later; these same patients were treated with Ketotifen in a dose of 1 mg every 12 hours for 5 days. In the blood samples, cAMP levels were determined through a method based on Gilman's technique (comparative protein binding) using the Cyclic AMP Assay Kit (The Radiochemical Center, England). Among the results obtained, there is a clear elevation of cAMP levels in all the determinations after the administration of Ketotifen, maintaining the circadian rhythm with a maximum peak in cAMP levels 5 hours after the drug was given. Thus an increase in all values when compared with basal levels were found arguing in favour of a protective action of this substance carried out through stabilization of the mast cell membrane and thus impeding the release of histamine.
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