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  • Title: Mechanism of phospholipid peroxidation induced by ferric ion-ADP-adriamycin-co-ordination complex.
    Author: Sugioka K, Nakano M.
    Journal: Biochim Biophys Acta; 1982 Nov 12; 713(2):333-43. PubMed ID: 6295497.
    Abstract:
    A system, which contains NADPH, purified cytochrome P-450 reductase and adriamycin, produces H2O2, O-2 and adriamycin semiquinone radical with O2 consumption and NADPH oxidation. This system, however, does not promote a peroxidation cleavage of unsaturated phospholipid. On the other hand, ferric ion-ADP-adriamycin-co-ordination complex, which may convert to a perferryl ion-co-ordination complex by an intramolecular electron transfer mechanism in air, acts as a powerful initiator for lipid peroxidation. A similar perferryl ion-co-ordination complex could also be produced from ferric ion-ADP-adriamycin-co-ordination complex after reducing it by NADPH-dependent cytochrome P-450 reductase in air.
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