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  • Title: [Association of hepatocellular adenoma and focal nodular hyperplasia of the liver in a woman on oral contraceptives].
    Author: Defrance R, Zafrani ES, Hannoun S, Saada M, Fagniez PL, Métreau JM.
    Journal: Gastroenterol Clin Biol; 1982 Nov; 6(11):949-50. PubMed ID: 6295869.
    Abstract:
    The case of a 37-year old woman with no previous pathology who developed liver adenoma and focal nodular hyperplasia after taking various oral contraceptive (OC) combined preparations over 15 years is described. The woman was hospitalized after discovery of a mass in the right hypochondrium. Other clinical findings were normal. During laparotomy 2 hepatic tumors were found: a mass 10 cm in diameter in the right lobe found at histological examination to be a focal nodular hyperplasia, and a mass 1 cm in diameter discovered fortuitously in the left lobe and which demonstrated the histological characteristics of a hepatic adenoma. The role of OCs in the development of hepatic adenomas is supported by epidemiological evidence, but the relationship between pills and focal nodular hyperplasia is much less clear. Although they occur in men and children, their development and the appearance of occasionally serious hemorrhagic complications appear to be encouraged by OCs. The complications are probably due to the vascular modifications observed in the tumor during OC use. The association of the 2 types of tumor in 1 patient has apparently been reported only once previously. Various hypotheses may be advanced to explain the occurrence.
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