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  • Title: Determination of left-ventricular volume from first-pass kinetics of labeled red cells.
    Author: Harpen MD, Dubuisson RL, Head GB, Parmley LF, Jones TB, Robinson AE.
    Journal: J Nucl Med; 1983 Feb; 24(2):98-103. PubMed ID: 6296337.
    Abstract:
    A mathematical model is presented for the dynamics of a bolus of technetium-99m-labeled red blood cells through the left ventricle. It is used to correct for attenuation the count rate observed over the left ventricle during a conventional gated blood-pool study. The left-ventricular volumes are calculated from the corrected count rates and expressed as a percentage of total blood volume, or in absolute terms if a blood sample is obtained. The procedure is applied to a number of patients with nonvalvular cardiac disease. Cardiac volumes determined by the method are found to correlate well (r = 0.98) with those determined by contrast left ventriculography. The method is simple, requires no special equipment, and can be applied with existing computer software.
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