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  • Title: Properties of vitamin E-deficient erythrocytes following peroxidant injury.
    Author: Lubin B, Chiu D.
    Journal: Pediatr Res; 1982 Nov; 16(11):928-32. PubMed ID: 6296751.
    Abstract:
    Several membrane properties of vitamin E-deficient and normal erythrocytes were studied after incubation of these cells with hydrogen peroxide. Measurements of mean corpuscular volume, cation permeability, membrane Na+, K+ ATPase activity, red cell filterability through 5 mu millipore filters, and membrane protein pattern on sodium dodecyle sulfate-gel electrophoresis revealed marked alterations before lysis. Vitamin E sufficient cells were unaffected by a similar incubation with hydrogen peroxide. We speculate that the changes in membrane function, which follow peroxidant injury, contribute to the shortened red cell survival in the vitamin E deficient state.
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