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  • Title: [Pathogenesis of the arterial hypertensive syndrome in Itsenko-Cushing disease].
    Author: Komissarenko IV, Slavnov VN, Cheban AK, Iakovlev AA, Demchenko NP.
    Journal: Probl Endokrinol (Mosk); 1982; 28(6):28-31. PubMed ID: 6296809.
    Abstract:
    The indices of central hemodynamics and renin-angiotensine-aldosterone system, as well as their relationship, were studied in patients with aggravated Icenko-Cushing's disease. A stable high arterial pressure, a raised total peripheral resistance, a decreased cardiac index, an increased blood corticotrophin, cortisol and aldosterone levels and an enhanced plasmatic renin activity were revealed. It is suggested that activation of the renin-angiotensin-aldosterone system stimulates the development of arterial hypertension in patients with Icenko-Cushing's disease, taking into account a significant role of this system in alteration of the central hemodynamics indices.
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