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  • Title: A note on dysenzymia in the liver of rats fed on zinc, an essential metal.
    Author: Rana SV, Agrawal VP, Bhardwaj NG.
    Journal: Gegenbaurs Morphol Jahrb; 1982; 128(6):953-60. PubMed ID: 6298052.
    Abstract:
    Although zinc in traces is essential for the growth and well being of the animal, however a long-term treatment has been found equally toxic to the liver and kidney. Present report describes its effects on few key enzymes viz. alkaline phosphatase, acid phosphatase, 5-nucleotidase, lipase, glucose-6-phosphatase, and cholinesterase in the liver of rat, Rattus rattus albino. Histochemical observations have provided visual evidences on Zn-induced dysenzymia. The results have further been interpreted in terms of its effects on cellular organelle, levels of enzyme protein and microenvironment of the hepatic parenchyma.
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