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  • Title: Morphine-like analgesic actions of enkephalin-like peptides containing the Tyr-Arg unit.
    Author: Takagi H, Amano H, Nakamura A, Kubota M, Nagase O, Yajima H.
    Journal: Life Sci; ; 31(20-21):2245-8. PubMed ID: 6298521.
    Abstract:
    The analgesic actions of some synthetically prepared peptides having the Tyr-D-Arg unit at the N terminal portion of met- and leu-enkephalin were measured by the intra-cisternal injection method in mice. Among them, Tyr-D-Arg-Gly-Phe (DR-4) induced the most potent naloxone-reversible analgesia and was also effective by s.c. injection. DR-4 showed the good affinity to mu-receptor, and the resistance to the enzymatic degradation.
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