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  • Title: Enkephalin metabolism in brain and its inhibition.
    Author: Schwartz JC, De La Baume S, Yi CC, Chaillet P, Marcais-Collado H, Costentin J.
    Journal: Prog Neuropsychopharmacol Biol Psychiatry; 1982; 6(4-6):665-71. PubMed ID: 6298893.
    Abstract:
    Various cerebral peptidases are able to hydrolyse the enkephalins into inactive fragments. Among these enzymes enkephalin-dipeptidylcarboxypeptidase ("enkephalinase") inhibited by thiorphan and a bestatin-sensitive aminopeptidase activity seem to play a key-role as "inactivating neuropeptidases". Their inhibition, in vitro as well as in vivo, leads to a protection of endogenous enkephalins and to antinociceptive effects.
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