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  • Title: [Stress analgesia in experimental burn shock].
    Author: Sinitsyn LN, Gelashvili SS.
    Journal: Biull Eksp Biol Med; 1983 Apr; 95(4):37-9. PubMed ID: 6299430.
    Abstract:
    Experiments with curarized and slightly anesthetised adult cats with burn shock have demonstrated pronounced depression of excitation transmission in associative and nonspecific afferent systems during somatic, sound and light stimulation. Effects controlling the activity of the cardiovascular system were facilitated in efferent systems. In white rats, burn shock led to an increase in the somatic and visceral pain threshold during the first 5 days. Rausedyl and naloxone reduced stress analgesia caused by burn shock in white rats. Burn shock enhanced opiate-like activity (beta-endorphine, beta-lipotropin) of the white rat forebrain as shown by radioimmunoassay. The data suggest that stress analgesia associated with experimental burn shock is likely to be accounted for by the increased production of endogenous opiates.
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