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  • Title: Guanine nucleotides can activate the insulin-stimulated phosphodiesterase in liver plasma membranes.
    Author: Heyworth CM, Rawal S, Houslay MD.
    Journal: FEBS Lett; 1983 Apr 05; 154(1):87-91. PubMed ID: 6299798.
    Abstract:
    The insulin-stimulated cyclic AMP phosphodiesterase from liver plasma membranes is shown to be activated upon incubation with guanine nucleotides in the presence of ATP. The non-hydrolysable analogue of ATP, adenylyl imidodiphosphate failed to substitute for ATP in achieving activation. GTP, its non-hydrolysable analogues p[NH]ppG and GTP-gamma-S, as well as GDP, all elicited activation. It is suggested that guanine nucleotides, and probably insulin, exert their effect on this enzyme through a distinct species of guanine nucleotide regulatory protein.
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