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  • Title: The degradation of normal and analogue-containing proteins in MRC-5 fibroblasts.
    Author: Dean RT, Riley PA.
    Journal: Biochim Biophys Acta; 1978 Mar 01; 539(2):230-7. PubMed ID: 629999.
    Abstract:
    Proteins containing the arginine analogue canavanine were degraded much more quickly in MRC-5 fibroblasts than those containing only normal amino acids. The degradation of both classes of protein could be well described by a pair of exponential curves, the first representing an early rapid degradation and the second, a slower phase. There were no general trends in the variation with passage number of the cells' ability to degrade either normal or analogue-containing proteins, as judged by the half-lives of proteins. But there was an increase in the proportion of labelled normal protein falling into the early rapid degradation phase as the cells senesced in culture.
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