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  • Title: Age-related change in parathyroid hormone-dependent cyclic AMP formation in rat kidney.
    Author: Marcus R, Gonzales D.
    Journal: Mech Ageing Dev; 1982 Dec; 20(4):353-60. PubMed ID: 6300573.
    Abstract:
    Parathyroid hormone (PTH) dependent cyclic AMP (cAMP) accumulation was evaluated in renal cortex from 2- and 12-month-old rats. Basal cAMP was lower, and responses to PTH were greater at all concentrations of hormone in kidney from 2-month-old rats. This difference was obliterated by prior removal of parathyroid glands. cAMP responses to calcitonin and both basal and hormone-stimulated adenylate cyclase activity were the same at both ages. The results suggest progressive loss of responsiveness to PTH with age, but at a site other than the receptor-adenylate cyclase complex. Blunted cAMP accumulation in year-old rats most likely reflects agonist-specific desensitization.
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