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  • Title: [Liver tumors induced in mice by prenatal and postnatal administration of ortho-aminoazotoluene].
    Author: Kolesnichenko TS, Popova NV, Shabad LM.
    Journal: Biull Eksp Biol Med; 1978 Feb; 85(2):199-202. PubMed ID: 630097.
    Abstract:
    The authors studied the prenatal and postnatal blastomogenic action of orthoaminoazotoluol (OAAT) on the liver of CBA mice. OAAT was administered to mice intragastrically in oil solution, thrice, 4 mg each time (a total of 12 mg). Twelve months after the OAAT administration tumours of the liver during the postnatal period were revealed in 89.3% of female mice (11.5% in control), and in 78.7% of male mice (68.5% in control). In the experimental progeny subjected to OAA action during last 4--5 days of the prenatal period the liver tumours appeared in females at the age of 12 months in 54.8% of cases (5.3% in control), and in males--in 81.1% (35.2% in control). In this progeny, particularly in the male animals malignant neoplasms occurred more frequently than in the intact animals and those subjected to the action of OAAT during the postnatal period.
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