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  • Title: Additive effects of epinephrine and corticotropin-releasing factor (CRF) on adrenocorticotropin release in rat anterior pituitary cells.
    Author: Giguère V, Labrie F.
    Journal: Biochem Biophys Res Commun; 1983 Jan 27; 110(2):456-62. PubMed ID: 6301454.
    Abstract:
    The ability of epinephrine to potentiate the action of corticotropin-releasing factor (CRF) was studied in rat anterior pituitary cells in primary culture. Increasing concentrations of epinephrine cause a maximal 6.5-fold stimulation of ACTH release while a 10-fold increase is induced by 5 nM CRF. The two substances exert an additive effect on ACTH release. Although epinephrine alone has no effect on cyclic AMP levels, it causes a maximal 4-fold increase in CRF-induced cyclic AMP accumulation. The stimulatory effect of epinephrine on both parameters is inhibited by the highly specific alpha 1-adrenergic antagonist prazosin but not by the beta-adrenergic antagonist (-)propranolol. Dexamethasone causes a 75% inhibition of ACTH release induced by the combined action of CRF and epinephrine. The present data show that the additive effect of epinephrine on CRF-induced ACTH release is achieved through an alpha-adrenergic receptor and is accompanied by a marked stimulation of intracellular cyclic AMP levels.
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