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  • Title: Isolation of a tumor cell laminin receptor.
    Author: Rao NC, Barsky SH, Terranova VP, Liotta LA.
    Journal: Biochem Biophys Res Commun; 1983 Mar 29; 111(3):804-8. PubMed ID: 6301485.
    Abstract:
    BL6 murine melanoma cells contain approximately 110,000 cell surface binding sites for the basement membrane glycoprotein laminin. Treatment of isolated melanoma cell plasma membranes with detergent yields a single class of laminin receptor. The receptor was purified 900 fold by laminin affinity chromatography. The isolated receptor has a Mr of 67,000 and binds laminin with high affinity: kd = 2 nm. The binding affinity of the isolated receptor was similar to that of the plasma membranes or the whole cells. Such a laminin receptor, isolated here for the first time, could facilitate the interaction of metastasizing tumor cells with the basement membrane.
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