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  • Title: Concentrations of ceftriaxone in serum and gynecological tissues.
    Author: Daschner FD, Petersen EE, Brändle J, Hillemanns HG.
    Journal: Chemotherapy; 1983; 29(2):153-5. PubMed ID: 6301774.
    Abstract:
    31 patients received an intravenous 15-min injection of 2 g ceftriaxone at various times before abdominal or vaginal hysterectomy. Ceftriaxone concentrations in salpinges were significantly higher than in myometrium and endometrium. Tissue concentrations of 20 micrograms/g could be maintained for at least 5 h. Due to its high tissue concentrations maintained for the whole operative procedure, ceftriaxone does seem to be one of the antibiotics of choice for single-dose prophylaxis of postoperative infections in gynecology.
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