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  • Title: Neurobehavioral actions of cannabichromene and interactions with delta 9-tetrahydrocannabinol.
    Author: Davis WM, Hatoum NS.
    Journal: Gen Pharmacol; 1983; 14(2):247-52. PubMed ID: 6301931.
    Abstract:
    1. Neither cannabichromene (CBC) nor delta 9-tetrahydrocannabinol (THC) protected mice from electroshock-induced seizures, although THC inhibited postictal mortality. Minor effects were produced on seizure latency and duration. 2. CBC had a weak analgetic action in mice; THC had a moderate and lengthy effect, which was potentiated at 2 hr by concurrent CBC. 3. Both CBC (10-75 mg/kg, i.p.) and THC (20 mg/kg) reduced motility of mice, the THC equalling the highest dose of CBC. 4. Performance of a conditioned avoidance response was strongly impaired by THC, but not by CBC, nor did CBC combined with THC have influence on the effects of THC.
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