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  • Title: Maternally derived immune resistance to fatal diarrhea in infant mice due to mouse hepatitis virus.
    Author: Ishida T, Fujiwara K.
    Journal: Jpn J Exp Med; 1982 Oct; 52(5):231-5. PubMed ID: 6302350.
    Abstract:
    Adult female ICR mice were able to produce high titered neutralizing antibodies to mouse hepatitis virus (MHV) by repeated intraperitoneal injections of formalin-inactivated virus. Offspring sucklings born to the immunized dams resisted to MHV causing fatal diarrhea, when their dams had a complement fixing antibody titer of 1:5 or higher. The protection was found to be mediated mainly through neutralizing IgG antibodies in the milk. Sucklings from non-immune dams were also protected by foster-nursing by immune mothers.
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