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  • Title: Experimental study in rabbits of the antishock effect of anisodamine (654-2), and its mechanism of action.
    Author: Su JY, Wu L, Tang C.
    Journal: Resuscitation; 1983 Feb; 10(3):173-84. PubMed ID: 6302797.
    Abstract:
    The antishock effect of anisodamine (654-2) was observed in different kinds of experimental shock in groups of rabbits--due to late hemorrhage, superior mesenteric artery occlusion, and septic shock from peritonitis. The drug 654-2 significantly alleviated the progress of shock and increased the survival rate of the animals. The therapeutic effect of 654-2 was much better than that of other vasoactive drugs commonly used, such as norepinephrine, phenoxybenzamine, dopamine, and aramine. The antishock mechanism of 654-2 is probably partly due to its protective action on intestinal shock in preventing its effects becoming irreversible. The antishock action of 654-2 both by basic research workers and clinicians merits further study.
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