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  • Title: Effects of insulin secretagogues and inhibitors on phospholipid metabolism in Langerhans' islets of rat pancreas.
    Author: Tanigawa K, Kuzuya H, Okamoto M, Imura H.
    Journal: Biochem Biophys Res Commun; 1983 Apr 29; 112(2):419-24. PubMed ID: 6303318.
    Abstract:
    Glucose stimulation of [32P]-prelabelled pancreatic islets induced an increased incorporation of radioactivity into phosphatidylinositol. Glucagon and agents that increases cAMP in the islet did not affect phosphatidylinositol turnover, in spite of increased release of insulin. Furthermore, the potent inhibitor of insulin release, somatostatin did not alter phospholipid metabolism. Colchicine inhibited glucose-stimulated turnover of phosphatidylinositol as well as insulin release. These results may suggest that: (1) cAMP and phosphatidylinositol turnover are involved in different transmembrane control system for regulating insulin release; and (2) the function of microtubules modulate phospholipid metabolism.
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