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  • Title: Anti-mutagenic chalcones: antagonizing the mutagenicity of benzo(a)pyrene on Salmonella typhimurium.
    Author: Torigoe T, Arisawa M, Itoh S, Fujiu M, Maruyama HB.
    Journal: Biochem Biophys Res Commun; 1983 May 16; 112(3):833-42. PubMed ID: 6303339.
    Abstract:
    Several chalcone derivatives; e.g. Ro 09-0204, Ro 09-0323 and Ro 09-0501 were found to reduce markedly the revertant increase of Salmonella typhimurium TA100 by benzo(a)pyrene during the incubation with S-9 Mix. The antimutagenic activity was 100 - 700 times stronger than that of L-ascorbic acid. Effect on other mutagens, the structure activity relationship and the possible mechanism of action are briefly discussed.
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