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  • Title: Anxiolytics block excessive grooming behavior induced by ACTH1-24 and bombesin.
    Author: Crawley JN, Moody TW.
    Journal: Brain Res Bull; 1983 Mar; 10(3):399-401. PubMed ID: 6303524.
    Abstract:
    Diazepam and meprobamate significantly attenuated the increases in grooming behavior induced by peptides. Significant increases in total grooming frequency over a thirty minute observation period were produced by intraventricular administration of 1 microgram ACTH1-24 and by 1 microgram bombesin to awake rats. Diazepam 1 mg/kg IP blocked the peptide-induced increases in grooming. Non-sedating doses of diazepam also completely reversed the grooming seen when rats were placed in a novel environment. The functional antagonism between anxiolytics and stress-related peptides supports the concept of interacting brain mechanisms mediating stress and anxiety.
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