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  • Title: Alteration of calcium transport by tumor promoters, 12-O-tetradecanoyl phorbol-13-acetate and p,p'-dichlorodiphenyltrichloroethane, in the Chinese hamster V79 fibroblast cell line.
    Author: Madhukar BV, Yoneyama M, Matsumura F, Trosko JE, Tsushimoto G.
    Journal: Cancer Lett; 1983 Apr; 18(3):251-9. PubMed ID: 6303558.
    Abstract:
    Effects of two tumor promoters, 12-O-tetradecanoyl phorbol-13-acetate (TPA) and p,p'-dichlorodiphenyltrichloroethane (DDT), on cellular calcium regulatory mechanisms were studied by using the Chinese hamster V79 fibroblast cell line. Both compounds at concentrations known to inhibit cell-cell communication, increased the cellular 45Ca2+ uptake and inhibited its efflux. DDT inhibited Ca,Mg-ATPase of the plasma membrane, while TPA stimulated cellular uptake of Ca2+. A working hypothesis has been proposed that the increase in intracellular concentration of Ca2+ by the action of these chemicals directly results in the closure of the central opening of the gap junction, and thereby causing a cessation of gap junction-mediated intercellular communication.
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