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  • Title: A technique for the preparation of Tc-99m red blood cells for evaluation of gastrointestinal hemorrhage.
    Author: Benedetto AR, Nusynowitz ML.
    Journal: Clin Nucl Med; 1983 Apr; 8(4):160-2. PubMed ID: 6303670.
    Abstract:
    Tc-99m labeled red blood cell (RBC) preparations are gaining wide acceptance in the diagnosis and localization of gastrointestinal bleeding. A major requirement of the radiopharmaceutical is that the percentage of Tc-99m attached to red cells in the injected dose must be extremely high, since free pertechnetate is secreted into the gastrointestinal tract and may obscure a bleeding site. We have developed a combined in vivo/in vitro labeling procedure which is simple and rapid, and which enables the administration of substantial amounts of RBC-bound Tc-99m and minimizes the amount of unbound technetium present. The technique is readily utilizable in any nuclear medicine clinic and requires no investigative pharmaceuticals.
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