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  • Title: Steroid-membrane-adenylate cyclase interactions during Xenopus laevis oocyte meiosis reinitiation: a new mechanism of steroid hormone action.
    Author: Baulieu EE.
    Journal: Exp Clin Endocrinol; 1983 Jan; 81(1):3-16. PubMed ID: 6303813.
    Abstract:
    Progesterone acts physiologically on Xenopus laevis oocyte meiosis reinitiation in interacting with plasma membrane. Hormonal studies indicate a specific "receptor-like" structure. The involvement of membrane adenylate cyclase activity which is selectively decreased by progesterone is described in intact oocytes as well as in a cell-free membrane containing system. The participation of Ca2+ changes and of phospholipid components of membrane is analyzed. We discuss the possibility that the progesterone-oocyte system is a model for understanding other steroid hormone activities in other target cells.
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