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  • Title: Changes in cGMP levels on meiosis reinitiation of starfish oocytes.
    Author: Nemoto S, Ishida K.
    Journal: Exp Cell Res; 1983 Apr 15; 145(1):226-30. PubMed ID: 6303819.
    Abstract:
    An intracellular level of cGMP (but not cAMP) transiently decreased the reinitiation of oocyte maturation in the starfish, Asterias amurensis. Exogenously applied cGMP inhibited hormone-induced maturation. Methylxanthines inhibited oocyte maturation by suppressing the decrease in cGMP levels. These results suggest that a decrease in cGMP levels is a prerequisite for meiosis reinitiation of starfish oocytes.
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