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  • Title: Poly(ADP-ribosylation) of a DNA topoisomerase.
    Author: Ferro AM, Higgins NP, Olivera BM.
    Journal: J Biol Chem; 1983 May 25; 258(10):6000-3. PubMed ID: 6304023.
    Abstract:
    A DNA topoisomerase activity, copurifying with poly(ADP-ribose) synthetase from calf thymus, is greater than 95% inhibited if extensive poly(ADP-ribosylation) is allowed to occur. The inhibited DNA topoisomerase, which has drastically different elution properties on hydroxylapatite, can be reactivated by mild alkaline treatment. These results are consistent with a poly(ADP-ribosylation) of the DNA topoisomerase and covalent attachment of the poly(ADP-ribose) moieties to the topoisomerase by alkali-labile bonds.
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