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  • Title: Effects of androgens on the activity of steroid-metabolizing enzymes in the murine submaxillary gland.
    Author: Katsukawa H, Tanabe Y, Funakoshi M.
    Journal: J Dent Res; 1983 Jun; 62(6):725-7. PubMed ID: 6304166.
    Abstract:
    Effects of androgens on the activity of androgen-metabolizing enzymes have been investigated in the murine submaxillary gland. 5 alpha-reductase activity is androgen-dependent, and 17 beta-hydroxysteroid dehydrogenase activity is androgen-resistant. The level and androgen-responsiveness of 5 alpha-reductase in the murine submaxillary gland are not imprinted during the neonatal period by testicular androgens. Circulating androgen may have a cumulative effect on androgen response of 5 alpha-reductase.
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