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  • Title: Inhibitory coupling of hormone and neurotransmitter receptors to adenylate cyclase.
    Author: Jakobs KH, Aktories K, Schultz G.
    Journal: J Recept Res; 1983; 3(1-2):137-49. PubMed ID: 6304293.
    Abstract:
    The last few years have provided evidence that beside the familiar and partially well characterized stimulation of the adenylate cyclase the enzyme is also subject to a hormone and neurotransmitter-induced inhibition serving as a general information-transfer system. Similar to hormonal stimulation, the coupling of the inhibitory hormone receptors to adenylate cyclase is mediated by a GTP-dependent process. In some membrane systems, the inhibitory coupling is additionally amplified by sodium ions. Inhibitory hormones stimulate a high affinity GTPase in plasma membranes. The observed correlation suggests that there is a close connection between the hormone-induced adenylate cyclase inhibition and GTPase stimulation. Several lines of evidence are presented suggesting that the guanine nucleotide-dependent component apparently involved in adenylate cyclase inhibition and apparently exhibiting GTPase activity is at least partially different from that involved in adenylate cyclase stimulation by hormones.
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