These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Paralysis in nude mice caused by polyomavirus-induced vertebral tumors.
    Author: Harper JS, Dawe CJ, Trapp BD, McKeever PE, Collins M, Woyciechowska JL, Madden DL, Sever JL.
    Journal: Prog Clin Biol Res; 1983; 105():359-67. PubMed ID: 6304770.
    Abstract:
    Eighty-one of 95 BaLB/c nude mice infected intracranially with the LID strain of polyomavirus developed tumors of the vertebrae which compressed the spinal cord or peripheral nerves and produced paralysis. Wallerian degeneration was the only pathological alteration found in the nervous system of polyoma-infected mice. While polyomavirus was demonstrated in the brain and spinal cord by viral isolation and immunoperoxidase staining, no evidence of a primary demyelinating process was found. The disease produced in the present study is not a satisfactory animal model of progressive multifocal leukoencephalopathy.
    [Abstract] [Full Text] [Related] [New Search]