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  • Title: [Membrane potential, permeability coefficients and the ratio of the influx/efflux rates for alkaline cations across the muscle fiber membrane of the frog in a bi-ionic system].
    Author: Vereninov AA, Toropova FV.
    Journal: Tsitologiia; 1983 Mar; 25(3):297-305. PubMed ID: 6304955.
    Abstract:
    Membrane potential and 42K, 22Na, 86Rb fluxes were measured in frog muscles immersed in sucrose--sulfate media with cation of one type. For elimination of the internal sodium and chloride ions muscles were preincubated in sucrose solution. It was found that dependence of membrane potential on the cation concentration deviated from the Goldman--Hodgkin--Katz relation. The variation in the permeability coefficients which should be assumed to correlate to experimental dependence with the Goldman--Hodgkin--Katz formula, were estimated. The required values of the permeability, coefficients were shown to differ from those found by fluxes. The influx/efflux rate constants ratio for all of the cations tested did not obey the Ussing criterion for independent passive movement of ion across membrane. It is concluded that the Goldman--Hodgkin--Katz formula cannot be used for a description of passive ion movement in the systems similar to those studied in this work.
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