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  • Title: Functional and morphologic changes associated with insulinoma transplantation into diabetic rats.
    Author: Reintgen DS, Croker B, Verveart C, Seigler HF.
    Journal: Am J Pathol; 1983 Jul; 112(1):1-6. PubMed ID: 6305199.
    Abstract:
    Because of the technical difficulties encountered with human islet cell transplantation, alternatives toward supplying the juvenile diabetic with an endogenous insulin source are sought. With the use of a streptozotocin-induced diabetic rat model, it was found that by transplantation of a benign insulinoma, the glomerular deposition of material stained by the periodic acid-Schiff method, IgG, IgM, and C3 may be prevented. This effect was found only when transplantation of the insulin-producing tumor occurred within 2-4 weeks of the induction of diabetes. The data suggest that successful insulinoma engraftment can prevent the glomerular mesangial lesions from developing.
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