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  • Title: Calcium-dependent activation and deactivation of rod outer segment phosphodiesterase is calmodulin-independent.
    Author: Del Priore LV, Lewis A.
    Journal: Biochem Biophys Res Commun; 1983 May 31; 113(1):317-24. PubMed ID: 6305354.
    Abstract:
    ATP-dependent activation and deactivation of retinal rod outer segment phosphodiesterase is affected by calcium [Kawamura, S. and Bownds, M. D., J. Gen. Physiol. 77:571-591(1981)]. Our data demonstrate that although calmodulin has been found in rod outer segments [Liu, Y. P. and Schwartz, H., Biochim. Biophys. Acta 526:186-193(1978); Kohnken, R. E. et al, J. Biol. Chem. 256:12517-12522(1981)], this protein is not involved in calcium-dependent phosphodiesterase activation at light levels at which calcium clearly affects this enzyme's activity. Furthermore, calmodulin does not mediate the calcium-dependent deactivation of phosphodiesterase.
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