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  • Title: Calmodulin-stimulated cyclic nucleotide phosphodiesterase from Neurospora crassa.
    Author: Ortega Perez R, Van Tuinen D, Marmé D, Turian G.
    Journal: Biochim Biophys Acta; 1983 Jul 05; 758(1):84-7. PubMed ID: 6305427.
    Abstract:
    Cyclic nucleotide phosphodiesterase has been partially purified by calmodulin-Sepharose affinity chromatography from a soluble extract of Neurospora crassa. The phosphodiesterase activity remained bound to the affinity column even in the presence of 6 M urea and could only be eluted by calcium chelation. The enzyme exhibits cAMP and cGMP phosphodiesterase activities. Both activities can be enhanced by calmodulin in a Ca2+-dependent manner. Stimulation of cyclic nucleotide phosphodiesterase by calmodulin can be inhibited by calmodulin antagonists such as pimozide, trifluoperazine and chlorpromazine.
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