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  • Title: Effect of prostaglandin A2 on Na+-K+-ATPase in basolateral plasma membrane of rat intestine in vitro inhibition of activation of K+-dependent p-nitrophenylphosphatase by Na+ and ATP.
    Author: Matsukawa R, Terao N, Hayakawa M, Takiguchi H.
    Journal: Int J Biochem; 1983; 15(5):739-41. PubMed ID: 6305739.
    Abstract:
    1. The activation of K+-dependent p-nitrophenylphosphatase (EC 3.6.1.7) by both Na+ and ATP in rat intestinal basolateral plasma membrane is inhibited by prostaglandin A2. 2. The drug's inhibition of the activation of the enzyme by both Na+ and ATP is due to a decrease in the affinity of the enzyme for Na+ and in the Vmax of the enzyme. 3. The Ki values for this drug for Na+ and ATP in the activation of the enzyme were 45 and 70 microM, respectively.
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