These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Alterations in beta adrenergic physiological response characteristics after long-term treatment with desmethylimipramine: interaction between norepinephrine and gamma-aminobutyric acid in rat cerebellum.
    Author: Yeh HH, Woodward DJ.
    Journal: J Pharmacol Exp Ther; 1983 Jul; 226(1):126-34. PubMed ID: 6306219.
    Abstract:
    Changes in beta adrenergically mediated responses of cerebellar Purkinje cells to norepinephrine (NE) were assessed in rats chronically treated with desmethylimipramine (DMI). A decreased efficacy of NE action after DMI pretreatment was manifested in both a higher mean iontophoretic current dose of the catecholamine required to induce threshold depressions of Purkinje cell spontaneous activity and a markedly diminished ability of NE to enhance inhibitory responses to gamma-aminobutyric acid. No significant differences were found in the responsiveness of Purkinje cells to gamma-aminobutyric acid alone between control and DMI-pretreated animals. However, in a significant portion of the Purkinje cells tested in the DMI-pretreated group, concurrent NE application resulted in an antagonism rather than an enhanced responsiveness to gamma-aminobutyric acid. The results of this electrophysiological study provide evidence for a "modulatory subsensitivity" toward noradrenergic actions in the cerebellum after a decrease in beta receptor number induced by prolonged treatment with DMI.
    [Abstract] [Full Text] [Related] [New Search]