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  • Title: The response of several adrenocortical steroids to the administration of ACTH in hirsute women.
    Author: Bongiovanni AM.
    Journal: J Steroid Biochem; 1983 Jun; 18(6):745-7. PubMed ID: 6306346.
    Abstract:
    Thirty-three women with hirsutism and oligomenorrhea were stimulated with synthetic adrenocorticotropin, as well as 12 controls. Of these test subjects 20 demonstrated significantly greater rises of serum levels of 3,17-dihydroxy-5-pregnen-20-one as well as dehydroepiandrosterone sulfate suggesting an attenuated deficiency of 3 beta-hydroxysteroid dehydrogenase. Five did not show similar rises of these compounds but revealed significant elevations of 17-hydroxyprogesterone as would be expected in 21-hydroxylase deficiency. None of the subjects were virilized. Eight additional hirsute women were not different than the normals. It appears that a subtle deficiency of 3 beta-hydroxysteroid dehydrogenase may be more common as an explanation of a syndrome resembling polycystic ovarian disease than has been previously recognized.
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